AEG 3482

CAS No. 63735-71-7

AEG 3482( —— )

Catalog No. M33767 CAS No. 63735-71-7

AEG 3482 is a potent antiapoptotic compound. AEG 3482 inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG 3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 46 In Stock
10MG 73 In Stock
25MG 159 In Stock
50MG 251 In Stock
100MG 355 In Stock
200MG 516 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    AEG 3482
  • Note
    Research use only, not for human use.
  • Brief Description
    AEG 3482 is a potent antiapoptotic compound. AEG 3482 inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG 3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25.
  • Description
    AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25.
  • In Vitro
    AEG3482 (0.3-30 μM; 2 d) inhibits nerve growth factor (NGF) withdrawal-induced death in SCG neurons, with an EC50 of ~20 μM.AEG3482 (1-80 μM; 40 h) inhibits p75NTR- and NRAGE- mediated apoptosis of PC12 cells in a dose-dependent manner. AEG3482 (10-40 μM; 30 h) inhibits p75NTR- and NRAGE-mediated JNK activation in PC12 cells.Apoptosis Analysis Cell Line:PC12 cells Concentration:1, 2.5, 5, 10, 20, 40, 80 μM Incubation Time:40 hours Result:Reduced p75NTR- or NRAGE-induced cell death by greater than 90% at the concentration of 40 μM.Exerted a slight toxic effect in cells infected with the LacZ control at the concentration of 80 μM.Western Blot Analysis Cell Line:PC12 cells Concentration:10, 20, 40 μM Incubation Time:30 hours Result:Attenuated p75NTR- and NRAGE-induced c-Jun phosphorylation and caspase-3 cleavage, and the levels of c-Jun protein.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    63735-71-7
  • Formula Weight
    280.33
  • Molecular Formula
    C10H8N4O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (891.81 mM; Ultrasonic )
  • SMILES
    NS(=O)(=O)c1nn2cc(nc2s1)-c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Salehi AH, et, al. AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem Biol. 2006 Feb;13(2):213-23.?
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